ketojenik diyetin kemik erimeisi yaptığı ie ilgili 5 yıllık araştıırma sonucu safsata olsuğu ortaya çıktı. gelişme çağındaki çocuklarla ilgili bir soru işareti var o da daha geniş araştırma gerektiriyor.
Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: a case series.
Bertoli S1, Trentani C2, Ferraris C2, De Giorgis V3, Veggiotti P3, Tagliabue A4.
Author information
Abstract
OBJECTIVE:
The only known treatment of glucose transporter 1 deficiency syndrome (GLUT-1 DS) is a ketogenic diet (KD), which provides the brain with an alternative fuel. Studies in children with intractable epilepsy have shown that a prolonged KD can induce a progressive loss of bone mineral content associated with poor bone health status, probably as a consequence of a chronic acidic environment. The aim of this study is to determine the long-term effects of a KD on body composition and bone mineral status of patients with GLUT-1 DS, is currently unknown.
METHODS:
In this case series, we report the changes in body composition and bone mineral status observed in three adult patients with GLUT-1 DS who have been treated with a KD for more than 5 y.
RESULTS:
A long-term KD did not produce appreciable changes in weight and body composition of adults with GLUT-1 DS. Moreover, we found no evidence of potential adverse effects of a KD on bone health. In summary, this case series contributes to a small but growing body of literature that investigated the potential long-term effects of a KD on bone health.
CONCLUSIONS:
Our data suggest that maintaining a KD for more than 5 y does not pose any major negative effects on body composition, bone mineral content, and bone mineral density in adults with GLUT-1 DS, a finding that is at variance with previous reports focusing on children with intractable epilepsy. Further studies with larger sizes are needed to confirm and expand our findings.
Copyright © 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Body composition; Bone health; Glucose transporter 1 deficiency syndrome; Ketogenic diet
PMID:
24800673
DOI:
10.1016/j.nut.2014.01.005
[Indexed for MEDLINE]
Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: a case series.
Bertoli S1, Trentani C2, Ferraris C2, De Giorgis V3, Veggiotti P3, Tagliabue A4.
Author information
Abstract
OBJECTIVE:
The only known treatment of glucose transporter 1 deficiency syndrome (GLUT-1 DS) is a ketogenic diet (KD), which provides the brain with an alternative fuel. Studies in children with intractable epilepsy have shown that a prolonged KD can induce a progressive loss of bone mineral content associated with poor bone health status, probably as a consequence of a chronic acidic environment. The aim of this study is to determine the long-term effects of a KD on body composition and bone mineral status of patients with GLUT-1 DS, is currently unknown.
METHODS:
In this case series, we report the changes in body composition and bone mineral status observed in three adult patients with GLUT-1 DS who have been treated with a KD for more than 5 y.
RESULTS:
A long-term KD did not produce appreciable changes in weight and body composition of adults with GLUT-1 DS. Moreover, we found no evidence of potential adverse effects of a KD on bone health. In summary, this case series contributes to a small but growing body of literature that investigated the potential long-term effects of a KD on bone health.
CONCLUSIONS:
Our data suggest that maintaining a KD for more than 5 y does not pose any major negative effects on body composition, bone mineral content, and bone mineral density in adults with GLUT-1 DS, a finding that is at variance with previous reports focusing on children with intractable epilepsy. Further studies with larger sizes are needed to confirm and expand our findings.
Copyright © 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Body composition; Bone health; Glucose transporter 1 deficiency syndrome; Ketogenic diet
PMID:
24800673
DOI:
10.1016/j.nut.2014.01.005
[Indexed for MEDLINE]
