Merhaba arkadaşlar,
Yabancı sitelerde tartışılan bir konuyu buraya taşımak istiyorum.
Öncelikle yayımlanmış birkaç makalenin çevirisiyle başlayayım.
"Oral arginine attenuates the growth hormone response to resistance exercise
S. R. Collier, E. Collins, and J. A. Kanaley
Department of Exercise Science, Syracuse University, Syracuse, New York
Submitted 7 March 2006 ; accepted in final form 23 May 2006
This study investigated the combined effect of resistance exercise and arginine ingestion on spontaneous growth hormone (GH) release. Eight healthy male subjects were studied randomly on four separate occasions [placebo, arginine (Arg), placebo + exercise (Ex), arginine + exercise (Arg+Ex)]. Subjects had blood sampled every 10 min for 3.5 h. After baseline sampling (30 min), subjects ingested a 7-g dose of arginine or placebo (blinded, randomly assigned). On the exercise days, the subject performed 3 sets of 9 exercises, 10 repetitions at 80% one repetition maximum. Resting GH concentrations were similar on each study day. Integrated GH area under the curve was significantly higher on the Ex day (508.7 ? 169.6 min?ng/ml; P < 0.05) than on any of the other study days. Arg+Ex (260.5 ? 76.8 min?ng/ml) resulted in a greater response than the placebo day but not significantly greater than the Arg day. The GH half-life and half duration were not influenced by the stimulus administered. The GH secretory burst mass was larger, but not significantly, on the Arg, Ex, and Arg+Ex day than the placebo day. Endogenous GH production rate (Ex > Arg+Ex > Arg > placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P < 0.05) but there were no differences between the Ex and Arg+Ex day. Oral arginine alone (7 g) stimulated GH release, but a greater GH response was seen with exercise alone. The combined effect of arginine before exercise attenuates the GH response. Autonegative feedback possibly causes a refractory period such that when the two stimuli are presented there will be suppression of the somatotrope."
Uzun uzadıya çeviri yapmayacağım arkadaşlar sadece etkilerden bahsedeceğim.
Yazıda egzersiz+l-arginin(pre-workout), tek başına egzersiz, tek başına l-arginin ve placebonun GH üzerine etkileri karşılaştırılmış.
Sonuç olarak şöyle bir tablo ortaya çıkmış:
Egzersiz>Egzersiz+l-arginin>l-arginin>placebo
Yani egzersiz öncesinde alınan l-arginin GH üzerinde negatif bir etki yapıyor.
Department of Exercise Science, University of Southern California, Los Angeles, USA. [email protected]
BACKGROUND: Growth hormone (GH) helps maintain body composition and metabolism in adults. However, basal and peak GH decline with age. Exercise produces a physiologic GH response that is subnormal in elderly people. Arginine (Arg) infusion can augment GH secretion, but the efficacy of oral Arg to improve GH response to exercise has not been explored. We investigated whether oral Arg increases GH secretion in young and old people at rest and during exercise. METHODS: Twenty young (Y: 22.1 +/- 0.9 y; SEM) and 8 old (O: 68.5 +/- 2.1 y) male and female subjects underwent three different trials following determination of their one-repetition maximum strength (1-RM); exercise only (EO; 3 sets, 8-10 reps at 85% of 1-RM; on 12 separate resistive lifts), Arg only (5.0 g), or Arg + exercise. Blood samples were collected between successive lifts, and GH (ng x ml(-1)) was determined via RIA. RESULTS: In Y vs O: Basal GH secreted (area under the curve) was 543.6 +/- 84.0 vs 211.5 +/- 63.0. During EO, values were 986.6 +/- 156.6 and 517.8 +/- 85.5. Both were significantly lower in the older individuals (p < .05). Oral Arg alone did not result in any increase in GH secretion at rest (310.8 +/- 73.2 vs 262.9 +/- 141.2). When Arg was coadministered during exercise, GH release was not affected in either the young or old and appeared to be blunted in the young compared to the exercise only trial in the young. CONCLUSION: Based upon these findings, we concluded that oral Arg does not stimulate GH secretion and may impair GH release during resistive exercise.
Yukarıdaki araştırmadan da aynı sonuç çıkmış arkadaşlar.
Fakat insanlar bir konuda ikiye ayrılmış:
"l-arginin antrenman sırasında GH' yi azaltsa da pump etkisiyle bunun önüne geçiyor" diyenler ve buna katılmayanlar olarak.
Şimdi tecrübe eden arkadaşlardan bilgilerini almak isterim bu konuda.
Ayrıca günlük kullanımı ve kaç gr alınması gerektiğinden de bahsederseniz sevinirim.
Genel bir kanı olarak günlük 5-10 gram arası l-arginin GH' yi uyarıyor deniyor.
Konuyu bilenlerden dinleyelim.
İyi çalışmalar...
Kaynak: http://forum.bodybuilding.com/showthread.php?t=1655191
http://www.ncbi.nlm.nih.gov/pubmed/10496544?dopt=AbstractPlus
Yabancı sitelerde tartışılan bir konuyu buraya taşımak istiyorum.
Öncelikle yayımlanmış birkaç makalenin çevirisiyle başlayayım.
"Oral arginine attenuates the growth hormone response to resistance exercise
S. R. Collier, E. Collins, and J. A. Kanaley
Department of Exercise Science, Syracuse University, Syracuse, New York
Submitted 7 March 2006 ; accepted in final form 23 May 2006
This study investigated the combined effect of resistance exercise and arginine ingestion on spontaneous growth hormone (GH) release. Eight healthy male subjects were studied randomly on four separate occasions [placebo, arginine (Arg), placebo + exercise (Ex), arginine + exercise (Arg+Ex)]. Subjects had blood sampled every 10 min for 3.5 h. After baseline sampling (30 min), subjects ingested a 7-g dose of arginine or placebo (blinded, randomly assigned). On the exercise days, the subject performed 3 sets of 9 exercises, 10 repetitions at 80% one repetition maximum. Resting GH concentrations were similar on each study day. Integrated GH area under the curve was significantly higher on the Ex day (508.7 ? 169.6 min?ng/ml; P < 0.05) than on any of the other study days. Arg+Ex (260.5 ? 76.8 min?ng/ml) resulted in a greater response than the placebo day but not significantly greater than the Arg day. The GH half-life and half duration were not influenced by the stimulus administered. The GH secretory burst mass was larger, but not significantly, on the Arg, Ex, and Arg+Ex day than the placebo day. Endogenous GH production rate (Ex > Arg+Ex > Arg > placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P < 0.05) but there were no differences between the Ex and Arg+Ex day. Oral arginine alone (7 g) stimulated GH release, but a greater GH response was seen with exercise alone. The combined effect of arginine before exercise attenuates the GH response. Autonegative feedback possibly causes a refractory period such that when the two stimuli are presented there will be suppression of the somatotrope."
Uzun uzadıya çeviri yapmayacağım arkadaşlar sadece etkilerden bahsedeceğim.
Yazıda egzersiz+l-arginin(pre-workout), tek başına egzersiz, tek başına l-arginin ve placebonun GH üzerine etkileri karşılaştırılmış.
Sonuç olarak şöyle bir tablo ortaya çıkmış:
Egzersiz>Egzersiz+l-arginin>l-arginin>placebo
Yani egzersiz öncesinde alınan l-arginin GH üzerinde negatif bir etki yapıyor.
Department of Exercise Science, University of Southern California, Los Angeles, USA. [email protected]
BACKGROUND: Growth hormone (GH) helps maintain body composition and metabolism in adults. However, basal and peak GH decline with age. Exercise produces a physiologic GH response that is subnormal in elderly people. Arginine (Arg) infusion can augment GH secretion, but the efficacy of oral Arg to improve GH response to exercise has not been explored. We investigated whether oral Arg increases GH secretion in young and old people at rest and during exercise. METHODS: Twenty young (Y: 22.1 +/- 0.9 y; SEM) and 8 old (O: 68.5 +/- 2.1 y) male and female subjects underwent three different trials following determination of their one-repetition maximum strength (1-RM); exercise only (EO; 3 sets, 8-10 reps at 85% of 1-RM; on 12 separate resistive lifts), Arg only (5.0 g), or Arg + exercise. Blood samples were collected between successive lifts, and GH (ng x ml(-1)) was determined via RIA. RESULTS: In Y vs O: Basal GH secreted (area under the curve) was 543.6 +/- 84.0 vs 211.5 +/- 63.0. During EO, values were 986.6 +/- 156.6 and 517.8 +/- 85.5. Both were significantly lower in the older individuals (p < .05). Oral Arg alone did not result in any increase in GH secretion at rest (310.8 +/- 73.2 vs 262.9 +/- 141.2). When Arg was coadministered during exercise, GH release was not affected in either the young or old and appeared to be blunted in the young compared to the exercise only trial in the young. CONCLUSION: Based upon these findings, we concluded that oral Arg does not stimulate GH secretion and may impair GH release during resistive exercise.
Yukarıdaki araştırmadan da aynı sonuç çıkmış arkadaşlar.
Fakat insanlar bir konuda ikiye ayrılmış:
"l-arginin antrenman sırasında GH' yi azaltsa da pump etkisiyle bunun önüne geçiyor" diyenler ve buna katılmayanlar olarak.
Şimdi tecrübe eden arkadaşlardan bilgilerini almak isterim bu konuda.
Ayrıca günlük kullanımı ve kaç gr alınması gerektiğinden de bahsederseniz sevinirim.
Genel bir kanı olarak günlük 5-10 gram arası l-arginin GH' yi uyarıyor deniyor.
Konuyu bilenlerden dinleyelim.
İyi çalışmalar...
Kaynak: http://forum.bodybuilding.com/showthread.php?t=1655191
http://www.ncbi.nlm.nih.gov/pubmed/10496544?dopt=AbstractPlus